Andrew D Krystal Selected Research

suvorexant

1/2019	Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications.
7/2017	Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.
6/2017	Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data.
2/2017	Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
1/2016	Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.
1/2016	Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials.
5/2014	Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.

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Andrew D Krystal Research Topics

Disease

52	Sleep Initiation and Maintenance Disorders (Insomnia) 10/2021 - 11/2003
9	Major Depressive Disorder (Major Depressive Disorders) 01/2021 - 02/2007
8	Sleepiness 01/2017 - 09/2006
4	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 10/2021 - 04/2007
4	Mental Disorders (Mental Disorder) 11/2020 - 07/2007
3	Sleep Wake Disorders 01/2020 - 01/2010
3	Cognitive Dysfunction 01/2019 - 03/2014
3	Pain (Aches) 06/2014 - 11/2005
3	Headache (Headaches) 02/2010 - 01/2008
2	Anhedonia 01/2020 - 01/2020
2	Parasomnias (Parasomnia) 01/2019 - 01/2017
2	Disorders of Excessive Somnolence (Hypersomnia) 01/2019 - 01/2017
2	Nocturia 01/2017 - 03/2013
2	Delirium 01/2017 - 04/2012
2	Schizophrenia (Dementia Praecox) 12/2014 - 05/2008
2	Bipolar Disorder (Manic Depressive Psychosis) 10/2014 - 04/2004
2	Obstructive Sleep Apnea 02/2014 - 01/2010
2	Weight Gain 10/2011 - 11/2010
2	Fatigue 01/2010 - 08/2007
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Hypoxia (Hypoxemia) 12/2020
1	Dementia (Dementias) 01/2019
1	Narcolepsy 12/2018
1	Critical Illness (Critically Ill) 01/2017
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/2016
1	Treatment-Resistant Depressive Disorder 11/2016
1	Substance-Related Disorders (Drug Abuse) 10/2016
1	Psychotic Disorders (Schizoaffective Disorder) 12/2014
1	Low Back Pain (Lumbago) 06/2014
1	Sleep Deprivation 03/2014
1	Emergence Delirium 04/2012
1	Anxiety Disorders (Anxiety Disorder) 01/2012
1	Nasopharyngitis 02/2010

Drug/Important Bio-Agent (IBA)

11	Antidepressive Agents (Antidepressants)IBA 11/2019 - 07/2007
10	Eszopiclone (Lunesta)FDA Link 02/2017 - 11/2003
8	Zolpidem (Ambien)FDA LinkGeneric 01/2021 - 08/2004
8	Hypnotics and Sedatives (Sedatives)IBA 11/2019 - 04/2005
7	Orexin Receptor AntagonistsIBA 01/2019 - 05/2014
7	suvorexantIBA 01/2019 - 05/2014
4	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2021 - 01/2004
4	Antipsychotic Agents (Antipsychotics)IBA 10/2019 - 05/2008
3	Trazodone (Trittico)FDA LinkGeneric 11/2020 - 02/2017
3	Therapeutic UsesIBA 01/2020 - 08/2010
3	OrexinsIBA 10/2019 - 01/2013
3	BenzodiazepinesIBA 10/2019 - 07/2007
3	Doxepin (Mareen)FDA LinkGeneric 02/2017 - 11/2010
3	Modafinil (Provigil)FDA Link 01/2017 - 01/2010
3	Cholinergic Antagonists (Anticholinergics)IBA 10/2011 - 11/2010
2	brexpiprazoleIBA 01/2021 - 09/2016
2	Oxygen (Dioxygen)IBA 12/2020 - 03/2014
2	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2020 - 10/2016
2	Melatonin Receptors (Melatonin Receptor)IBA 10/2019 - 07/2007
2	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 12/2018 - 01/2011
2	MelatoninIBA 02/2017 - 08/2012
2	Tiagabine (Gabitril)FDA Link 02/2017 - 05/2014
2	zaleplon (Sonata)FDA LinkGeneric 02/2017 - 01/2011
2	GABA-A Receptors (GABA(A) Receptor)IBA 01/2017 - 03/2016
2	Serotonin (5 Hydroxytryptamine)IBA 08/2015 - 01/2004
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2015 - 07/2007
2	Butyric Acid (Butanoic Acid)IBA 05/2014 - 08/2013
2	Pharmaceutical PreparationsIBA 08/2013 - 06/2012
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	florbetapirIBA 01/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	Opioid Analgesics (Opioids)IBA 01/2020
1	N-acetyltalosaminuronic acid (NAT)IBA 01/2020
1	Opioid Receptors (Opioid Receptor)IBA 01/2020
1	Anticonvulsants (Antiepileptic Drugs)IBA 10/2019
1	Histamine H1 AntagonistsIBA 10/2019
1	Histamine Antagonists (Antihistamines)IBA 10/2019
1	Sertraline (Zoloft)FDA LinkGeneric 02/2017
1	Diphenhydramine (Benadryl)FDA LinkGeneric 02/2017
1	Tryptophan (L-Tryptophan)FDA Link 02/2017
1	Triazolam (Halcion)FDA LinkGeneric 02/2017
1	Escitalopram FDA Link 02/2017
1	Desvenlafaxine Succinate FDA Link 02/2017
1	ramelteon (Rozerem)FDA Link 02/2017
1	Temazepam (Nocturne)FDA LinkGeneric 02/2017
1	MK-6096IBA 01/2017
1	Dexmedetomidine FDA Link 01/2017
1	Biological ProductsIBA 12/2016
1	5-Hydroxytryptophan (5 Hydroxytryptophan)IBA 11/2016
1	Narcotic Antagonists (Opioid Antagonists)IBA 10/2016
1	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2016
1	Lurasidone Hydrochloride FDA Link 01/2016
1	gamma-Aminobutyric Acid (GABA)IBA 08/2015
1	Naproxen (Naprosyn)FDA LinkGeneric 06/2014
1	GABA Uptake InhibitorsIBA 05/2014
1	Indicators and Reagents (Reagents)IBA 05/2014
1	Histamine (Histamine Dihydrochloride)FDA Link 08/2013
1	Bumetanide (Bumex)FDA LinkGeneric 01/2012
1	Furosemide (Lasix)FDA LinkGeneric 01/2012
1	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2012

Therapy/Procedure

26	Therapeutics 01/2021 - 01/2004
9	Drug Therapy (Chemotherapy) 10/2021 - 07/2005
2	Transcranial Magnetic Stimulation 01/2018 - 07/2015
2	Continuous Positive Airway Pressure 02/2014 - 01/2010
2	Duration of Therapy 08/2009 - 07/2005
1	Orthopedic Procedures 01/2017
1	Knee Replacement Arthroplasty (Total Knee Replacement) 04/2012